The 3-E students storm the enemy, who has launched a deadly biological attack. Their path is blocked by three master assassins.

"Mr. Karasuma gives the E-3 students super-powered uniforms...with great results. What feats can they perform in their snazzy new outfits? Then, Mr. Karasuma gives Ms. Vitch a bouquet for her birthday...with disasterous results. Next, a E-3 teacher is kidnapped by master assassin the Grim Reaper, who threatens to kill his hostage if the students tell anyone. Their rescue attempt goes horribly awry, and soon they are the ones in need to rescuing! But...

"The latest addition to the misfit students of Class 3-E is a Norwegian robot specially designed to assassinate their teacher-- but sadly lacking in social skills. Nothing Koro Sensei can't cure with a little super-fast tentacle work! When playboy Maehara gets dissed by a girl for being in Class 3-E, revenge is clearly warranted and Koro Sensei can help with that too! Then Irina, the English language teacher/ sexy assassin, gets a visit from her murder...

As lowly Class E and elite Class A compete for customers at their school festival booths, a parade of familiar faces, some welcome and some not, drop by Class E's booth with surprising consequences.

"Ever caught yourself screaming, "I could just kill that teacher"? What would it take to justify such antisocial behavior and weeks of detention? Especially if he's the best teacher you've ever had? Giving you an "F" on a quiz? Mispronouncing your name during roll call... again? How about blowing up the moon and threatening to do the same to Mother Earth--unless you take him out first?! Plus a reward of a cool 100 million from the Ministry of Defense!...

The 3-E students discover that Koro Sensei's greatest weakness might be a common substance. Will they be able to use it to assassinate him while he helps Meg, formerly of the varsity swim team, with her greatest weakness? The next assassination attempt, implemented by Terasaka, is more elaborate but endangers his fellow students. Can he save them without saving his target? Then, the top class at school, including Principal Asano's son, conspires to...

"Koro Sensei's lessons in verbal defense are put to the test when Karma must use his brains instead of his brawn to rescue a classmate. Then things finally begin to go smoothly for the students of 3-E. Everyone receives some good news about their futures, and Nagisa settles on a career goal. But the peace is broken when the world's nations miraculously manage to coordinate their efforts long enough to launch a plan to assassinate Koro Sensei--with...

"Ever caught yourself screaming, "I could just kill that teacher"? What would it take to justify such antisocial behavior and weeks of detention? Especially if he's the best teacher you've ever had? Giving you an "F" on a quiz? Mispronouncing your name during roll call...again? How about blowing up the moon and threatening to do the same to Mother Earth--unless you take him out first?! Plus a reward of a cool 100 million from the Ministry of Defense!...

A graphic novel adaptation of William Shakespeare's play about the first emperor of ancient Rome, the conspiracy to assassinate him, and the civil war that follows his murder.